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Following a horrendous season, the club suffered a shattering tragedy when Manolo Preciado , appointed as Villarreal's new manager on 6 June , died of a heart attack later that day.

The team began its new tenure in the top-flight by winning its first three games; the winning streak ended with a tie against Real Madrid at El Madrigal, though the team was undefeated until falling to Real Betis 1—0 in the seventh matchday of the season.

The Yellow Submarine finished the —14 campaign in sixth, thus qualifying them for next season's Europa League. In —15 , Villarreal again finished the year in sixth, enough to secure direct qualification to the Europa League group stage.

In the —16 season, Villarreal led La Liga for the first time during the sixth and seventh weeks, before falling to fifth place the following week.

The club progressed to the semi final Europa League , but were knocked out 3—1 on aggregate by Liverpool.

Villarreal led the first leg 1—0, but lost 3—0 in Liverpool. They also rival Valencia , since the two had been the most competitive teams of the Valencian Community ; this clash is called the " Derbi de la Comunitat.

The club's famous yellow kit dates back to With the new season fast approaching, the son of the then Villarreal president travelled to Valencia to purchase replacements of the club's official kit of white shirts and black shorts.

Discovering that the shop had neither in stock, he instead bought the only colour that they did have, which happened to be yellow.

The players voted that they should be dyed blue. From to 30 June , the shirt sponsor was "Aeroport Castello", an airport. The current shirt sponsor is Pamesa, a ceramics company.

From the —17 season, the kit is made by Joma , having previously been produced by the Chinese company Xtep and Puma of Germany among others.

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Further, these mice responded dramatically to conditions that induce cardiac hypertrophy, whereas mice overexpressing Sirt3 were protected from cardiac hypertrophy under the same conditions.

Additional analysis revealed the mechanism by which Sirt3 blocks the cardiac hypertrophic response, thereby providing protection to the mouse heart.

Specifically, it acts in heart muscle cells via the protein Foxo3a to increase expression of anti-oxidant proteins, thereby reducing levels of damaging oxidants.

TITLE: Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice AUTHOR: Mahesh P.

Gupta University of Chicago, Chicago, Illinois, USA. PDF of this article Source: Karen Honey Journal of Clinical Investigation.

Pathogenic Attacks On Host Plants Have Medicinal Research Implications. Two Kansas State University researchers focusing on rice genetics are providing a better understanding of how pathogens take over a plant's nutrients.

Their research provides insight into ways of reducing crop losses or developing new avenues for medicinal research. Frank White, professor of plant pathology, and Ginny Antony, postdoctoral fellow in plant pathology, are co-authors, in partnership with researchers at three other institutions, of an article in a recent issue of the journal Nature.

The article, "Sugar transporters for intercellular exchange and nutrition of pathogens," was led by Li-Qing Chen from the department of plant biology in the Carnegie Institution for Science at Stanford University.

The project involves the identification a family of sugar transporters, called SWEETS, which transport glucose between plant cells.

These transporters are also important because they are targeted by pathogens trying to obtain plant sugar for nutrition. The proteins take over the transcription of the SWEET gene, and the plant, as a consequence, becomes susceptible to bacterial disease.

The K-State researchers discovered three resistance genes in rice that can be mutated in order to build the resistance of the rice against a pathogen.

One of these resistance genes -- Xa13 -- is included in the Nature article and was discovered by White's lab in For the plant, these genes are involved in normal development.

However, once the pathogen takes control of expression, it makes the plant susceptible. They collaborated with researchers from Iowa State University to investigate a second susceptibility gene and its role in the spread of disease.

White's laboratory has been working on such rice research for 15 years, but started collaborating with the Stanford researchers earlier this year.

Although the research is important in the field of plant genetics, it has broader applications as well. Because researchers have a better understanding of how to control pathogen food supplies, they can use this research to reduce crop diseases and subsequent losses.

The plant research may also apply the findings to humans or animals because both use similar sugar transporter genes to transfer glucose, leading to new possibilities for medicine and diabetes research.

Department of Agriculture's National Research Initiative program through the Cooperative State Research, Education and Extension Service.

Source: Frank White Kansas State University. Molecular Prosthesis Against Gout. Researchers from the ETH Zurich's Department of Biosystems Science and Engineering D-BSSE have devised a new method for preventing and permanently eradicating the cause of gout.

It involves implanting a biological network that regulates the uric acid levels autonomously. As Paracelsus once stated, the dose makes the poison.

This not only goes for chemical substances introduced to the body, but also those produced by it. The uric acid in the blood especially needs to be in the proper dosage.

If the level is too high i. However, uric acid is an important part of the human detoxification system, acting as a so-called "scavenger" of free radicals, which cause neurological disorders, brain diseases and tumors.

A team of re-searchers headed by Professor Martin Fussenegger from ETH Zurich's D-BSSE in Basle has now succeeded in building a network of genes which permanently keep the uric acid concentration in check.

The preliminary trials in mice have been encouraging. First and foremost, this would include Ericsson ERIC and Nokia NOK.

Relative to the current cyberwar raging across the globe, investors should consider a basket of related names as a core holding. In this regard, two ETFs are specifically dedicated to cybersecurity: First Trust NASDAQ Cybersecurity ETF NASDAQ: CIBR and the ETFMG Prime Cyber Security ETF NYSEARCA: HACK.

Happy hunting in a target-rich environment. Home About Contact Interviews Articles Publications Consulting Media Opportunities.

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